MENU

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

Rolnik, DL; Wright, D; Poon, LC; O'Gorman, N; Syngelaki, A; Matallana, CD; Akolekar, R; Cicero, S; Janga, D; Singh, M; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Papaioannou, G; Tenenbaum-Gavish, K; Meiri, H; Gizurarson, S; Maclagan, K; Nicolaides, K

NEW ENGLAND JOURNAL OF MEDICINE
2017
VL / 377 - BP / 613 - EP / 622
abstract
BACKGROUND Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia. METHODS In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, at a dose of 150 mg per day, or placebo from 11 to 14 weeks of gestation until 36 weeks of gestation. The primary outcome was delivery with preeclampsia before 37 weeks of gestation. The analysis was performed according to the intention-to-treat principle. RESULTS A total of 152 women withdrew consent during the trial, and 4 were lost to follow up, which left 798 participants in the aspirin group and 822 in the placebo group. Preterm preeclampsia occurred in 13 participants (1.6%) in the aspirin group, as compared with 35 (4.3%) in the placebo group (odds ratio in the aspirin group, 0.38; 95% confidence interval, 0.20 to 0.74; P = 0.004). Results were materially unchanged in a sensitivity analysis that took into account participants who had withdrawn or were lost to follow-up. Adherence was good, with a reported intake of 85% or more of the required number of tablets in 79.9% of the participants. There were no significant between-group differences in the incidence of neonatal adverse outcomes or other adverse events. CONCLUSIONS Treatment with low-dose aspirin in women at high risk for preterm preeclampsia resulted in a lower incidence of this diagnosis than placebo.
105th Global

AccesS level

Green Published, Bronze

Mentions data

PAPER MENTIONS
Clinical Medicine
  •   Twitter
  • 1.2K
  •   Wikipedia
  • 0
  •   News
  • 56
  •   Policy
  • 1
Global Ranking
  •   Twitter
  • 1.2K
  •   Wikipedia
  • 0
  •   News
  • 56
  •   Policy
  • 1

Mentions Chart

Influratio by dimension
  • Twitter
  • Wikipedia
  • News
  • Policy
PAPER MENTIONS
  •   Twitter
  • 1.2K
  •   Wikipedia
  • 0
  •   News
  • 56
  •   Policy
  • 1
PROYECTO FINANCIADO POR PLAN NACIONAL DE INVESTIGACIÓN AGENCIA ESTATAL DE INVESTIGACIÓN, MINISTERIO DE CIENCIA E INNOVACIÓN. PID2019-109127RB-I00