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Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity

Guallar, MP; Meirino, R; Donat-Vargas, C; Corral, O; Jouve, N; Soriano, V

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2020
VL / 97 - BP / 290 - EP / 292
abstract
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
63rd Global

AccesS level

DOAJ Gold, Green Published

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PROYECTO FINANCIADO POR PLAN NACIONAL DE INVESTIGACIÓN AGENCIA ESTATAL DE INVESTIGACIÓN, MINISTERIO DE CIENCIA E INNOVACIÓN. PID2019-109127RB-I00