MENU

RETRACTED: Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial (Retracted article. See vol. 7, pg. 334, 2019)

Estruch, R; Martinez-Gonzalez, MA; Corella, D; Salas-Salvado, J; Fito, M; Chiva-Blanch, G; Fiol, M; Gomez-Gracia, E; Aros, F; Lapetra, J; Serra-Majem, L; Pinto, X; Buil-Cosiales, P; Sorli, JV; Munoz, MA; Basora-Gallisa, J; Lamuela-Raventos, RM; Serra-Mir,

LANCET DIABETES & ENDOCRINOLOGY
2016
VL / 4 - BP / 666 - EP / 676
abstract
Background Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese. Methods PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. 7447 asymptomatic men (aged 55-80 years) and women (aged 60-80 years) who had type 2 diabetes or three or more cardiovascular risk factors were randomly assigned (1: 1: 1) with a computer-generated number sequence to one of three interventions: Mediterranean diet supplemented with extra-virgin olive oil (n=2543); Mediterranean diet supplemented with nuts (n=2454); or a control diet (advice to reduce dietary fat; n=2450). Energy restriction was not advised, nor was physical activity promoted. In this analysis of the trial, we measured bodyweight and waist circumference at baseline and yearly for 5 years in the intention-to-treat population. The PREDIMED trial is registered with ISRCTN.com, number ISRCTN35739639. Findings After a median 4.8 years (IQR 2.8-5.8) of follow-up, participants in all three groups had marginally reduced bodyweight and increased waist circumference. The adjusted difference in 5 year changes in bodyweight in the Mediterranean diet with olive oil group was -0.43 kg (95% CI -0.86 to -0.01; p=0.044) and in the nut group was -0.08 kg (-0.50 to 0.35; p=0.730), compared with the control group. The adjusted difference in 5 year changes in waist circumference was -0.55 cm (-1.16 to -0.06; p=0.048) in the Mediterranean diet with olive oil group and -0.94 cm (-1.60 to -0.27; p=0.006) in the nut group, compared with the control group. Interpretation A long-term intervention with an unrestricted-calorie, high-vegetable-fat Mediterranean diet was associated with decreases in bodyweight and less gain in central adiposity compared with a control diet. These results lend support to advice not restricting intake of healthy fats for bodyweight maintenance.
49th Global

AccesS level

Bronze

Mentions data

PAPER MENTIONS
Clinical Medicine
  •   Twitter
  • 714
  •   Wikipedia
  • 0
  •   News
  • 184
  •   Policy
  • 0
Global Ranking
  •   Twitter
  • 714
  •   Wikipedia
  • 0
  •   News
  • 184
  •   Policy
  • 0

Mentions Chart

Influratio by dimension
  • Twitter
  • Wikipedia
  • News
  • Policy
PAPER MENTIONS
  •   Twitter
  • 714
  •   Wikipedia
  • 0
  •   News
  • 184
  •   Policy
  • 0
PROYECTO FINANCIADO POR PLAN NACIONAL DE INVESTIGACIÓN AGENCIA ESTATAL DE INVESTIGACIÓN, MINISTERIO DE CIENCIA E INNOVACIÓN. PID2019-109127RB-I00