Gold-Triggered Uncaging Chemistry in Living Systems
Perez-Lopez, AM; Rubio-Ruiz, B; Sebastian, V; Hamilton, L; Adam, C; Bray, TL; Irusta, S; Brennan, PM; Lloyd-Jones, GC; Sieger, D; Santamaria, J; Unciti-Broceta, A
Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.
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