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A lipidome atlas in MS-DIAL 4

Tsugawa, H; Ikeda, K; Takahashi, M; Satoh, A; Mori, Y; Uchino, H; Okahashi, N; Yamada, Y; Tada, I; Bonini, P; Higashi, Y; Okazaki, Y; Zhou, ZW; Zhu, ZJ; Koelmel, J; Cajka, T; Fiehn, O; Saito, K; Arita, M; Arita, M

NATURE BIOTECHNOLOGY
2020
VL / 38 - BP / 1159 - EP / +
abstract
Mass spectral fragmentations of lipids across 117 lipid subclasses are presented in a lipidome atlas. We present Mass Spectrometry-Data Independent Analysis software version 4 (MS-DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-section and tandem mass spectrometry information. We formulated mass spectral fragmentations of lipids across 117 lipid subclasses and included ion mobility tandem mass spectrometry. Using human, murine, algal and plant biological samples, we annotated and semiquantified 8,051 lipids using MS-DIAL 4 with a 1-2% estimated false discovery rate. MS-DIAL 4 helps standardize lipidomics data and discover lipid pathways.

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PROYECTO FINANCIADO POR PLAN NACIONAL DE INVESTIGACIÓN AGENCIA ESTATAL DE INVESTIGACIÓN, MINISTERIO DE CIENCIA E INNOVACIÓN. PID2019-109127RB-I00