Pharmacology & Toxicology
Listando 34 trabajos del autor/autora 38
Lista de trabajos en el área Pharmacology & Toxicology
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Article
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease
Grinan-Ferre, Christian; Codony, Sandra; Pujol, Eugenia; Yang, Jun; Leiva, Rosana; Escolano, Carmen; Puigoriol-Illamola, Dolors; Companys-Alemany, Julia; Corpas, Ruben; Sanfeliu, Coral; Perez, Belen; Isabel Loza, M.; Brea, Jose; Morisseau, Christophe; Hamm
NEUROTHERAPEUTICS
1933-7213 (2020)
DOI /
10.1007/s13311-020-00854-1
Green accepted, Bronze, Green published, Green submitted
Mentions
20
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10
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Article
Benzofuranyl-2-imidazoles as imidazoline I-2 receptor ligands for Alzheimer's disease
Rodriguez-Arevalo, Sergio; Bagan, Andrea; Grinan-Ferre, Christian; Vasilopoulou, Foteini; Pallas, Merce; Brocos-Mosquera, Iria; Callado, Luis F.; Isabel Loza, M.; Martinez, Anton L.; Brea, Jose; Perez, Belen; Molins, Elies; De Jonghe, Steven; Daelemans, Di
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2021)
DOI /
10.1016/j.ejmech.2021.113540
Mentions
65
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8
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Article
Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I-2 Receptor Ligands for Alzheimer's Disease
Abas, Sonia; Rodriguez-Arevalo, Sergio; Bagan, Andrea; Grinan-Ferre, Christian; Vasilopoulou, Foteini; Brocos-Mosquera, Iria; Muguruza, Carolina; Perez, Belen; Molins, Elies; Javier Luque, F.; Perez-Lozano, Pilar; De Jonghe, Steven; Daelemans, Dirk; Naesen
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.9b02080
Green accepted, Green submitted
Mentions
36
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1
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Article
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6
Javier Perez-Areales, F.; Garrido, Maria; Aso, Ester; Bartolini, Manuela; De Simone, Angela; Espargaro, Alba; Ginex, Tiziana; Sabate, Raimon; Perez, Belen; Andrisano, Vincenza; Puigoriol-Illamola, Dolors; Pallas, Merce; Javier Luque, F.; Isabel Loza, Maria
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.0c00528
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13
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1
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Article
Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease
Jaiteh, Mariama; Zeifman, Alexey; Saarinen, Marcus; Svenningsson, Per; Brea, Jose; Loza, Maria Isabel; Carlsson, Jens
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2018)
DOI /
10.1021/acs.jmedchem.8b00204
Bronze, Green published
Mentions
32
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Article
Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A(2B) Adenosine Receptor Antagonists
Mallo-Abreu, Ana; Prieto-Diaz, Ruben; Jespers, Willem; Azuaje, Jhonny; Majellaro, Maria; Velando, Carmen; Garcia-Mera, Xerardo; Caamatio, Olga; Brea, Jose; Loza, Maria, I; Gutierrez-de-Teran, Hugo; Sotelo, Eddy
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.0c00564
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17
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1
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Article
5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines
Toro-Sazo, Miguel; Brea, Jose; Loza, Maria I.; Cimadevila, Marta; Cassels, Bruce K.
PLOS ONE
1932-6203 (2019)
DOI /
10.1371/journal.pone.0209804
Green published, Gold other
Mentions
26
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From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
Codony, Sandra; Calvo-Tusell, Carla; Valverde, Elena; Osuna, Silvia; Morisseau, Christophe; Isabel Loza, M.; Brea, Jose; Perez, Concepcion; Isabel Rodriguez-Franco, Maria; Pizarro-Delgado, Javier; Corpas, Ruben; Grinan-Ferre, Christian; Pallas, Merce; Sanf
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2021)
DOI /
10.1021/acs.jmedchem.0c01601
Mentions
16
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3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A(2B) Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Majellaro, Maria; Jespers, Willem; Crespo, Abel; Nunez, Maria J.; Novio, Silvia; Azuaje, Jhonny; Prieto-Diaz, Ruben; Gioe, Claudia; Alispahic, Belma; Brea, Jose; Loza, Maria, I; Freire-Garabal, Manuel; Garcia-Santiago, Carlota; Rodriguez-Garcia, Carlos; Ga
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2021)
DOI /
10.1021/acs.jmedchem.0c01431
Mentions
21
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Docking Finds GPCR Ligands in Dark Chemical Matter
Ballante, Flavio; Rudling, Axel; Zeifman, Alexey; Luttens, Andreas; Duy Duc Vo; Irwin, John J.; Kihlberg, Jan; Brea, Jose; Isabel Loza, Maria; Carlsson, Jens
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.9b01560
Mentions
19
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From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
Pont, Caterina; Ginex, Tiziana; Grinan-Ferre, Christian; Scheiner, Matthias; Mattellone, Alexia; Martinez, Noemi; Arce, Elsa M.; Soriano-Fernandez, Yolanda; Naldi, Marina; De Simone, Angela; Barenys, Marta; Gomez-Catalan, Jesus; Perez, Belen; Sabate, Raimo
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2021)
DOI /
10.1016/j.ejmech.2021.113779
Hybrid
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1
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1
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Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain
Martinez, Anton L.; Brea, Jose; Dominguez, Eduardo; Varela, Maria J.; Cimadevila, Marta; Allegue, Catarina; Cruz, Raquel; Monroy, Xavier; Merlos, Manuel; Burgueno, Javier; Carracedo, Angel; Loza, Maria, I
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2021)
DOI /
10.1021/acschemneuro.1c00129
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2
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1
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A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
Companys-Alemany, Julia; Turcu, Andreea L.; Bellver-Sanchis, Aina; Loza, Maria, I; Brea, Jose M.; Canudas, Anna M.; Leiva, Rosana; Vazquez, Santiago; Pallas, Merce; Grinan-Ferre, Christian
PHARMACEUTICS
(2020)
DOI /
10.3390/pharmaceutics12030284
Green published, Gold
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1
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1
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Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases
Bolognino, Isabella; Giangregorio, Nicola; Tonazzi, Annamaria; Martinez, Anton L.; Altomare, Cosimo D.; Loza, Maria, I; Sablone, Sara; Cellamare, Saverio; Catto, Marco
CHEMMEDCHEM
1860-7179 (2021)
DOI /
10.1002/cmdc.202100209
Green published, Hybrid
Mentions
10
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0
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Article
Effect of Nitrogen Atom Substitution in A(3) Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists
Azuaje, Jhonny; Jespers, Willem; Yaziji, Vicente; Mallo, Ana; Majellaro, Maria; Caamano, Olga; Loza, Maria I.; Cadavid, Maria I.; Brea, Jose; Aqvist, Johan; Sotelo, Eddy; Gutierrez-de-Teran, Hugo
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2017)
DOI /
10.1021/acs.jmedchem.7b00860
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14
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0
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His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics
Martin-Guerrero, Sandra M.; Alonso, Paula; Iglesias, Alba; Cimadevila, Marta; Brea, Jose; Isabel Loza, M.; Casado, Pedro; Martin-Oliva, David; Cutillas, Pedro R.; Gonzalez-Maeso, Javier; Lopez-Gimenez, Juan F.
BIOCHEMICAL PHARMACOLOGY
0006-2952 (2021)
DOI /
10.1016/j.bcp.2021.114440
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7
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2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis
Codony, Sandra; Pujol, Eugenia; Pizarro, Javier; Feixas, Ferran; Valverde, Elena; Isabel Loza, M.; Brea, Jose M.; Saez, Elena; Oyarzabal, Julen; Pineda-Lucena, Antonio; Perez, Belen; Perez, Concepcion; Isabel Rodriguez-Franco, Maria; Leiva, Rosana; Osuna,
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.0c00310
Green accepted, Green submitted
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8
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Perturbation Theory/Machine Learning Model of ChEMBL Data for Dopamine Targets: Docking, Synthesis, and Assay of New L-Prolyk-L-leucyl-glycinamide Peptidomimetics
Ferreira da Costa, Joana; Silva, David; Caamano, Olga; Brea, Jose M.; Isabel Loza, Maria; Munteanu, Cristian R.; Pazos, Alejandro; Garcia-Mera, Xerardo; Gonzalez-Diaz, Humbert
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2018)
DOI /
10.1021/acschemneuro.8b00083
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2
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Serotonin-2A homodimers are needed for signalling via both phospholipase A(2) and phospholipase C in transfected CHO cells
Iglesias, Alba; Cimadevila, Marta; Cadavid, Maria Isabel; Loza, Maria Isabel; Brea, Jose
EUROPEAN JOURNAL OF PHARMACOLOGY
0014-2999 (2017)
DOI /
10.1016/j.ejphar.2017.02.028
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3
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Synthesis, Pharmacological, and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R
Sampaio-Dias, Ivo E.; Silva-Reis, Sara C.; Garcia-Mera, Xerardo; Brea, Jose; Isabel Loza, M.; Alves, Carla S.; Algarra, Manuel; Rodriguez-Borges, Jose E.
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2019)
DOI /
10.1021/acschemneuro.9b00259
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7
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Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
Azuaje, Jhonny; Lopez, Paula; Iglesias, Alba; de la Fuente, Rocio A.; Perez-Rubio, Jose M.; Garcia, Diego; Maciej Stepniewski, Tomasz; Garcia-Mera, Xerardo; Brea, Jose M.; Selent, Jana; Perez, Dolores; Castro, Marian; Loza, Maria I.; Sotelo, Eddy
SCIENTIFIC REPORTS
2045-2322 (2017)
DOI /
10.1038/s41598-017-11370-2
Gold DOAJ, Green published
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3
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Editorial Material
Editorial: Novel Approaches to the Neuropharmacology of Mood Disorders
Caruncho, Hector J.; Kalynchuk, Lisa E.; Loza, Maria I.; Olivares, Jose M.
FRONTIERS IN PHARMACOLOGY
(2019)
DOI /
10.3389/fphar.2019.00589
Gold DOAJ, Green published
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4
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Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway
Alvarez-Coiradas, Elia; Munteanu, Cristian R.; Diaz-Saez, Laura; Pazos, Alejandro; Huber, Kilian V. M.; Isabel Loza, Maria; Dominguez, Eduardo
INTERNATIONAL IMMUNOPHARMACOLOGY
1567-5769 (2020)
DOI /
10.1016/j.intimp.2020.107026
Green submitted
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6
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Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R)
Spinelli, Francesco; Giampietro, Roberta; Stefanachi, Angela; Riganti, Chiara; Kopecka, Joanna; Abatematteo, Francesca Serena; Leonetti, Francesco; Colabufo, Nicola Antonio; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; Perrone, Maria Grazia; Brea, Jose
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2020)
DOI /
10.1016/j.ejmech.2020.112037
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2
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Discovery of New Potent Positive Allosteric Modulators of Dopamine D-2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide
Sampaio-Dias, Ivo E.; Reis-Mendes, Ana; Costa, Vera Marisa; Garcia-Mera, Xerardo; Brea, Jose; Isabel Loza, Maria; Pires-Lima, Beatriz L.; Alcoholado, Cristina; Algarra, Manuel; Rodriguez-Borges, Jose E.
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2021)
DOI /
10.1021/acs.jmedchem.1c00252
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5
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
Lacivita, Enza; Niso, Mauro; Mastromarino, Margherita; Silva, Andrea Garcia; Resch, Cibell; Zeug, Andre; Loza, Maria, I; Castro, Marian; Ponimaskin, Evgeni; Leopoldo, Marcello
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2021)
DOI /
10.1021/acschemneuro.0c00647
Gold other
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2
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Synthesis, Pharmacological, and Biological Evaluation of 2-FuroylBased MIF-1 Peptidomimetics and the Development of a GeneralPurpose Model for Allosteric Modulators (ALLOPTML)
Sampaio-Dias, Ivo E.; Rodriguez-Borges, Jose E.; Yanez-Perez, Victor; Arrasate, Sonia; Llorente, Javier; Brea, Jose M.; Bediaga, Harbil; Vina, Dolores; Isabel Loza, Maria; Caamano, Olga; Garcia-Mera, Xerardo; Gonzalez-Diaz, Humberto
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2021)
DOI /
10.1021/acschemneuro.0c00687
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3
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Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug
Pfluger, Pricila; Pereira, Patricia; Loza, Maria I.; Brea, Jose; Vina, Dolores; Kumar, Amit; Fontenla, Jose A.
EUROPEAN JOURNAL OF PHARMACOLOGY
0014-2999 (2021)
DOI /
10.1016/j.ejphar.2021.174276
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2
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Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M
Arago, Marc; Moreno-Felici, Juan; Abas, Sonia; Rodriguez-Arevalo, Sergio; Hyrossova, Petra; Figueras, Agnes; Vinals, Francesc; Perez, Belen; Loza, Maria, I; Brea, Jose; Latorre, Pedro; Carrodeguas, Jose A.; Garcia-Roves, Pablo M.; Galdeano, Carlos; Ginex,
BIOMEDICINE & PHARMACOTHERAPY
0753-3322 (2020)
DOI /
10.1016/j.biopha.2019.109601
Gold other
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2
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Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease
Garcia, Ana M.; Salado, Irene G.; Perez, Daniel I.; Brea, Jose; Morales-Garcia, Jose A.; Gonzalez-Garcia, Alejandro; Cadavid, MariaIsabel; Isabel Loza, Maria; Javier Luque, Francisco; Perez-Castillo, Ana; Martinez, ANA; Gil, Carmen
FUTURE MEDICINAL CHEMISTRY
1756-8919 (2017)
DOI /
10.4155/fmc-2017-0005
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1
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
Kondej, Magda; Wrobel, Tomasz M.; Silva, Andrea G.; Stepnicki, Piotr; Koszla, Oliwia; Kedzierska, Ewa; Bartyzel, Agata; Biala, Grazyna; Matosiuk, Dariusz; Loza, Maria I.; Castro, Marian; Kaczor, Agnieszka A.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2019)
DOI /
10.1016/j.ejmech.2019.07.050
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1
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Modeling ANXA2-overexpressing circulating tumor cells homing and high throughput screening for metastasis impairment in endometrial carcinomas
Herrero, Carolina; Brea, Jose; Perez-Diaz, Amparo; Cuadrado, Emiliano; Ferreno, Noelia; Pablo Moiola, Cristian; Colas, Eva; Gil-Moreno, Antonio; Lopez-Lopez, Rafael; Isabel Loza, Maria; Abal, Miguel; Alonso-Alconada, Lorena
BIOMEDICINE & PHARMACOTHERAPY
0753-3322 (2021)
DOI /
10.1016/j.biopha.2021.111744
Hybrid
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2-Aryladenine derivatives as a potent scaffold for A(1), A(3) and dual A(1)/A(3) adenosine receptor antagonists: Synthesis and structure-activity relationships
Areias, Filipe; Correia, Carla; Rocha, Ashly; Brea, Jose; Castro, Marian; Loza, Maria, I; Fernanda Proenca, M.; Alice Carvalho, M.
BIOORGANIC & MEDICINAL CHEMISTRY
0968-0896 (2019)
DOI /
10.1016/j.bmc.2019.06.034
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Essential role of the C148-C227 disulphide bridge in the human 5-HT2A homodimeric receptor
Cimadevila, M.; Gomez-Garcia, L.; Martinez, A. L.; Iglesias, A.; Lopez-Gimenez, J.; Castro, M.; Cadavid, M., I; Loza, M., I; Brea, J.
BIOCHEMICAL PHARMACOLOGY
0006-2952 (2020)
DOI /
10.1016/j.bcp.2020.113985
