Clinical Medicine


  Listando 44 trabajos del autor/autora 38
Lista de trabajos en el área Clinical Medicine
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Article Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function Lima, Natalia da Silva; Fondevila, Marcos F.; Novoa, Eva; Buque, Xabier; Mercado-Gomez, Maria; Gallet, Sarah; Gonzalez-Rellan, Maria J.; Fernandez, Uxia; Loyens, Anne; Garcia-Vence, Maria; Chantada-Vazquez, Maria del Pilar; Bravo, Susana B.; Maranon, Patri JOURNAL OF HEPATOLOGY (2021) DOI / 10.1016/j.jhep.2021.09.008
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Review Endocrine-disrupting chemicals and the regulation of energy balance Nadal, Angel; Quesada, Ivan; Tuduri, Eva; Nogueiras, Ruben; Alonso-Magdalena, Paloma NATURE REVIEWS ENDOCRINOLOGY 1759-5029 (2017) DOI / 10.1038/nrendo.2017.51
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Article Functional identity of hypothalamic melanocortin neurons depends on Tbx3 Quarta, Carmelo; Fisette, Alexandre; Xu, Yanjun; Collden, Gustav; Legutko, Beata; Tseng, Yu-Ting; Reim, Alexander; Wierer, Michael; De Rosa, Maria Caterina; Klaus, Valentina; Rausch, Rick; Thaker, Vidhu V.; Graf, Elisabeth; Strom, Tim M.; Poher, Anne-Laure NATURE METABOLISM (2019) DOI / 10.1038/s42255-018-0028-1 Green submitted, Green accepted
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Article MKK6 controls T3-mediated browning of white adipose tissue Matesanz, Nuria; Bernardo, Edgar; Acin-Perez, Rebeca; Manieri, Elisa; Perez-Sieira, Sonia; Hernandez-Cosido, Lourdes; Montalvo-Romeral, Valle; Mora, Alfonso; Rodriguez, Elena; Leiva-Vega, Luis; Victoria Lechuga-Vieco, Ana; Ruiz-Cabello, Jesus; Torres, Jorg NATURE COMMUNICATIONS (2017) DOI / 10.1038/s41467-017-00948-z Green published, Gold
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Article Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control Ramirez, Sara; Gomez-Valades, Alicia G.; Schneeberger, Marc; Varela, Luis; Haddad-Tovolli, Roberta; Altirriba, Jordi; Noguera, Eduard; Drougard, Anne; Flores-Martinez, Alvaro; Imbernon, Monica; Chivite, Inigo; Pozo, Macarena; Vidal-Itriago, Andres; Garcia, CELL METABOLISM 1550-4131 (2017) DOI / 10.1016/j.cmet.2017.05.010 Bronze
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Article Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity Schriever, Sonja C.; Kabra, Dhiraj G.; Pfuhlmann, Katrin; Baumann, Peter; Baumgart, Emily, V; Nagler, Joachim; Seebacher, Fabian; Harrison, Luke; Irmler, Martin; Kullmann, Stephanie; Correa-da-Silva, Felipe; Giesert, Florian; Jain, Ruchi; Schug, Hannah; Ca JOURNAL OF CLINICAL INVESTIGATION 0021-9738 (2020) DOI / 10.1172/jci136363 Green published, Green submitted, Bronze
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Letter Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points Fondevila, Marcos F.; Mercado-Gomez, Maria; Rodriguez, Amaia; Gonzalez-Rellan, Maria J.; Iruzubieta, Paula; Valenti, Victor; Escalada, Javier; Schwaninger, Markus; Prevot, Vincent; Dieguez, Carlos; Crespo, Javier; Fruehbeck, Gema; Martinez-Chantar, Maria L JOURNAL OF HEPATOLOGY 0168-8278 (2021) DOI / 10.1016/j.jhep.2020.09.027 Bronze, Green submitted, Green published
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Article Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function Duquenne, Manon; Folgueira, Cintia; Bourouh, Cyril; Millet, Marion; Silva, Anisia; Clasadonte, Jerome; Imbernon, Monica; Fernandois, Daniela; Martinez-Corral, Ines; Kusumakshi, Soumya; Caron, Emilie; Rasika, S.; Deliglia, Eleonora; Jouy, Nathalie; Oishi, A NATURE METABOLISM (2021) DOI / 10.1038/s42255-021-00432-5
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Article SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression Vazquez, M. J.; Toro, C. A.; Castellano, J. M.; Ruiz-Pino, F.; Roa, J.; Beiroa, D.; Heras, V; Velasco, I; Dieguez, C.; Pinilla, L.; Gaytan, F.; Nogueiras, R.; Bosch, M. A.; Ronnekleiv, O. K.; Lomniczi, A.; Ojeda, S. R.; Tena-Sempere, M. NATURE COMMUNICATIONS (2018) DOI / 10.1038/s41467-018-06459-9 Gold DOAJ, Green published
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Article Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease Gomez-Santos, Beatriz; Saenz De Urturi, Diego; Nunez-Garcia, Maitane; Gonzalez-Romero, Francisco; Buque, Xabier; Aurrekoetxea, Igor; Gutierrez de Juan, Virginia; Gonzalez-Rellan, Maria J.; Garcia-Monzon, Carmelo; Gonzalez-Rodriguez, Agueda; Mosteiro, Loren AGING CELL 1474-9718 (2020) DOI / 10.1111/acel.13183 Green published, Gold
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Article Small extracellular vesicle-mediated targeting of hypothalamic AMPK alpha 1 corrects obesity through BAT activation Milbank, Edward; Dragano, Nathalia R. V.; Gonzalez-Garcia, Ismael; Garcia, Marcos Rios; Rivas-Limeres, Veronica; Perdomo, Liliana; Hilairet, Gregory; Ruiz-Pino, Francisco; Mallegol, Patricia; Morgan, Donald A.; Iglesias-Rey, Ramon; Contreras, Cristina; Ver NATURE METABOLISM (2021) DOI / 10.1038/s42255-021-00467-8
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Article Hypothalamic dopamine signalling regulates brown fat thermogenesis Folgueira, Cintia; Beiroa, Daniel; Porteiro, Begona; Duquenne, Manon; Puighermanal, Emma; Fondevila, Marcos F.; Barja-Fernandez, Silvia; Gallego, Rosalia; Hernandez-Bautista, Rene; Castelao, Cecilia; Senra, Ana; Seoane-Collazo, Patricia; Gomez-Lado, Noemi; NATURE METABOLISM (2019) DOI / 10.1038/s42255-019-0099-7 Green accepted
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Article Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons Lhomme, Tori; Clasadonte, Jerome; Imbernon, Monica; Fernandois, Daniela; Sauve, Florent; Caron, Emilie; Lima, Natalia da Silva; Heras, Violeta; Martinez-Corral, Ines; Mueller-Fielitz, Helge; Rasika, Sowmyalakshmi; Schwaninger, Markus; Nogueiras, Ruben; Pre JOURNAL OF CLINICAL INVESTIGATION 0021-9738 (2021) DOI / 10.1172/jci140521 Bronze
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Review Brain JNK and metabolic disease Nogueiras, Ruben; Sabio, Guadalupe DIABETOLOGIA 0012-186X (2020) DOI / 10.1007/s00125-020-05327-w Bronze
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Article Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly Simon, Jorge; Nunez-Garcia, Maitane; Fernandez-Tussy, Pablo; Barbier-Torres, Lucia; Fernandez-Ramos, David; Gomez-Santos, Beatriz; Buque, Xabier; Lopitz-Otsoa, Fernando; Goikoetxea-Usandizaga, Naroa; Serrano-Macia, Marina; Rodriguez-Agudo, Ruben; Bizkargue CELL METABOLISM 1550-4131 (2020) DOI / 10.1016/j.cmet.2020.01.013 Green accepted, Bronze, Green published
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Article Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis Gomez-Valades, Alicia G.; Pozo, Macarena; Varela, Luis; Boudjadja, Mehdi Boutagouga; Ramirez, Sara; Chivite, Inigo; Eyre, Elena; Haddad-Tovolli, Roberta; Obri, Arnaud; Mila-Guasch, Maria; Altirriba, Jordi; Schneeberger, Marc; Imbernon, Monica; Garcia-Rendu CELL METABOLISM 1550-4131 (2021) DOI / 10.1016/j.cmet.2021.07.008 Green published, Hybrid
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Review Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis Al-Massadi, Omar; Dieguez, Carlos; Schneeberger, Marc; Lopez, Miguel; Schwaninger, Markus; Prevot, Vincent; Nogueiras, Ruben NATURE REVIEWS ENDOCRINOLOGY 1759-5029 (2021) DOI / 10.1038/s41574-021-00559-1
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Article Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Contreras, Cristina; Varela, Luis; Villarroya, Joan; Rial-Pensado, Eva; Buque, Xabier; Aurrekoetxea, Igor; Delgado, Teresa C.; Vazquez-Martinez, Rafael; Gonzalez-Garcia, Ismael; Roa, Juan; Whittle, Andrew CELL METABOLISM 1550-4131 (2017) DOI / 10.1016/j.cmet.2017.06.014 Green published, Green accepted, Hybrid
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Article p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 Quinones, Mar; Al-Massadi, Omar; Folgueira, Cintia; Bremser, Stephan; Gallego, Rosalia; Torres-Leal, Leonardo; Haddad-Tovolli, Roberta; Garcia-Caceres, Cristina; Hernandez-Bautista, Rene; Lam, Brian Y. H.; Beiroa, Daniel; Sanchez-Rebordelo, Estrella; Senra NATURE COMMUNICATIONS (2018) DOI / 10.1038/s41467-018-05711-6 Green published, Gold
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Article Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity Contreras, Cristina; Gonzalez-Garcia, Ismael; Seoane-Collazo, Patricia; Martinez-Sanchez, Noelia; Linares-Pose, Laura; Rial-Pensado, Eva; Ferno, Johan; Tena-Sempere, Manuel; Casals, Nuria; Dieguez, Carlos; Nogueiras, Ruben; Lopez, Miguel DIABETES 0012-1797 (2017) DOI / 10.2337/db15-1547 Bronze
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Article Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma Lopez-Canovas, Juan L.; Del Rio-Moreno, Mercedes; Garcia-Fernandez, Helena; Jimenez-Vacas, Juan M.; Trinidad Moreno-Montilla, M.; Sanchez-Frias, Marina E.; Amado, Victor; L-Lopez, Fernando; Fondevila, Marcos F.; Ciria, Ruben; Gomez-Luque, Irene; Briceno, J CANCER LETTERS 0304-3835 (2021) DOI / 10.1016/j.canlet.2020.10.010
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Article Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut-to-brain axis Rastelli, Marialetizia; Van Hul, Matthias; Terrasi, Romano; Lefort, Charlotte; Regnier, Marion; Beiroa, Daniel; Delzenne, Nathalie M.; Everard, Amandine; Nogueiras, Ruben; Luquet, Serge; Muccioli, Giulio G.; Cani, Patrice D. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 0193-1849 (2020) DOI / 10.1152/ajpendo.00146.2020
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Article Thyroid hormones induce browning of white fat Martinez-Sanchez, Noelia; Moreno-Navarrete, Jose M.; Contreras, Cristina; Rial-Pensado, Eva; Ferno, Johan; Nogueiras, Ruben; Dieguez, Carlos; Fernandez-Real, Jose-Manuel; Lopez, Miguel JOURNAL OF ENDOCRINOLOGY 0022-0795 (2017) DOI / 10.1530/joe-16-0425 Green published, Hybrid, Green submitted
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Article Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis Serrano-Macia, Marina; Simon, Jorge; Gonzalez-Rellan, Maria J.; Azkargorta, Mikel; Goikoetxea-Usandizaga, Naroa; Lopitz-Otsoa, Fernando; de Urturi, Diego Saenz; Rodriguez-Agudo, Ruben; Lachiondo-Ortega, Sofia; Mercado-Gomez, Maria; de Juan, Virginia Gutier MOLECULAR METABOLISM 2212-8778 (2021) DOI / 10.1016/j.molmet.2021.101275 Green published, Gold
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Article Short regulatory DNA sequences to target brain endothelial cells for gene therapy Grasshoff, Hanna; Mueller-Fielitz, Helge; Dogbevia, Godwin K.; Koerbelin, Jakob; Bannach, Jacqueline; Vahldieck, Carl M. G.; Kusche-Vihrog, Kristina; Joehren, Olaf; Mueller, Oliver J.; Nogueiras, Ruben; Prevot, Vincent; Schwaninger, Markus JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 0271-678X (2021) DOI / 10.1177/0271678x211039617
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Article The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis Fondevila, Marcos F.; Fernandez, Uxia; Gonzalez-Rellan, Maria J.; Da Silva Lima, Natalia; Buque, Xabier; Gonzalez-Rodriguez, Agueda; Alonso, Cristina; Iruarrizaga-Lejarreta, Marta; Delgado, Teresa C.; Varela-Rey, Marta; Senra, Ana; Garcia-Outeiral, Vera; N HEPATOLOGY 0270-9139 (2020) DOI / 10.1002/hep.31290 Gold other, Green published
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Article Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty Folgueira, Cintia; Barja-Fernandez, Silvia; Gonzalez-Saenz, Patricia; Castelao, Cecilia; Vazquez-Cobela, Rocio; Pena-Leon, Veronica; Ruiz-Pinon, Manuel; Casanueva, Felipe F.; Dieguez, Carlos; Leis, Rosaura; Nogueiras, Ruben; Seoane, Luisa M. SCIENTIFIC REPORTS 2045-2322 (2018) DOI / 10.1038/s41598-018-32767-7 Green published, Gold
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Review GPR55: a new promising target for metabolism? Tuduri, Eva; Imbernon, Monica; Javier Hernandez-Bautista, Rene; Tojo, Marta; Ferno, Johan; Dieguez, Carlos; Nogueiras, Ruben JOURNAL OF MOLECULAR ENDOCRINOLOGY 0952-5041 (2017) DOI / 10.1530/jme-16-0253 Bronze
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Article Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery Ejarque, Miriam; Borlaug, Marianne; Vilarrasa, Nuria; Martinez-Perez, Bruno; Llaurado, Gemma; Megia, Ana; Helland, Thomas; Gutierrez, Cristina; Serena, Carolina; Folkestad, Oddry; Nunez-Roa, Catalina; Roche, Kelly; Casajoana, Ana; Fradera, Rosa; Miguel Gon TRANSLATIONAL RESEARCH 1931-5244 (2017) DOI / 10.1016/j.trsl.2017.03.001
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Article The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet Iglesias, Cristina; Floridian, Ebel; Sartages, Miriam; Porteiro, Begona; Frailel, Maria; Guerrero, Ana; Santos, Diana; Cuiiarro, Juan; Tovar, Sulay; Nogueiras, Ruben; Pombo, Celia M.; Zalvide, Juan DIABETOLOGIA 0012-186X (2017) DOI / 10.1007/s00125-017-4433-x Bronze
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Article Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis Porteiro, Begona; Fondevila, Marcos F.; Buque, Xabier; Gonzalez-Rellan, Maria J.; Fernandez, Uxia; Mora, Alfonso; Beiroa, Daniel; Senra, Ana; Gallego, Rosalia; Ferno, Johan; Lopez, Miguel; Sabio, Guadalupe; Dieguez, Carlos; Aspichueta, Patricia; Nogueiras, MOLECULAR METABOLISM 2212-8778 (2018) DOI / 10.1016/j.molmet.2017.12.005 Green published, Gold
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Article Central nicotine induces browning through hypothalamic kappa opioid receptor Seoane-Collazo, Patricia; Linares-Pose, Laura; Rial-Pensado, Eva; Romero-Pico, Amparo; Maria Moreno-Navarrete, Jose; Martinez-Sanchez, Noelia; Garrido-Gil, Pablo; Iglesias-Rey, Ramon; Morgan, Donald A.; Tomasini, Naoki; Malone, Samuel Andrew; Senra, Ana; F NATURE COMMUNICATIONS (2019) DOI / 10.1038/s41467-019-12004-z Green published, Gold
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Article Activation of Hypothalamic AMP-Activated Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis Seoane-Collazo, Patricia; Rial-Pensado, Eva; Estevez-Salguero, Anxela; Milbank, Edward; Garcia-Caballero, Lucia; Rios, Marcos; Linares-Pose, Laura; Scotece, Morena; Gallego, Rosalia; Manuel Fernandez-Real, Jose; Nogueiras, Ruben; Dieguez, Carlos; Gualillo, ARTHRITIS & RHEUMATOLOGY (2021) DOI / 10.1002/art.41950
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Article MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance Al-Massadi, Omar; Quinones, Mar; Clasadonte, Jerome; Hernandez-Bautista, Rene; Romero-Pico, Amparo; Folgueira, Cintia; Morgan, Donald A.; Kallo, Imre; Heras, Violeta; Senra, Ana; Funderburk, Samuel C.; Krashes, Michael J.; Souto, Yara; Fidalgo, Miguel; Luq DIABETES 0012-1797 (2019) DOI / 10.2337/db19-0029 Green published, Green accepted, Bronze
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Review The gut-brain axis: regulating energy balance independent of food intake Nogueiras, Ruben EUROPEAN JOURNAL OF ENDOCRINOLOGY 0804-4643 (2021) DOI / 10.1530/eje-21-0277 Hybrid, Green published
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Article Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women Garces, Maria Fernanda; Rodriguez-Navarro, Haiver Antonio; Buell-Acosta, Julieth Daniela; Burgos-Cardenas, Alvaro Javier; Franco-Vega, Roberto; Maldonado-Acosta, Luis Miguel; Eslava-Schmalbach, Javier; Parada-Banos, Arturo Jose; Castro-Pinzon, Andres; Sanc FRONTIERS IN ENDOCRINOLOGY 1664-2392 (2021) DOI / 10.3389/fendo.2021.670357 Gold DOAJ, Green published
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Editorial Material Insulinotropic Actions of GLP-1: How Much in the Brain and How Much in the Periphery? Tuduri, Eva; Nogueiras, Ruben ENDOCRINOLOGY 0013-7227 (2017) DOI / 10.1210/en.2017-00410 Bronze
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Article SF1-Specific AMPK alpha 1 Deletion Protects Against Diet-Induced Obesity Seoane-Collazo, Patricia; Roa, Juan; Rial-Pensado, Eva; Linares-Pose, Laura; Beiroa, Daniel; Ruiz-Pino, Francisco; Lopez-Gonzalez, Tania; Morgan, Donald A.; Angel Pardavila, Jose; Jesus Sanchez-Tapia, Maria; Martinez-Sanchez, Noelia; Contreras, Cristina; F DIABETES 0012-1797 (2018) DOI / 10.2337/db17-1538 Green published, Bronze
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Review Uroguanylin: a new actor in the energy balance movie Folgueira, C.; Barja-Fernandez, S.; Gonzalez-Saenz, P.; Pena-Leon, V.; Castelao, C.; Ruiz-Pinon, M.; Casanueva, F. F.; Nogueiras, R.; Seoane, L. M. JOURNAL OF MOLECULAR ENDOCRINOLOGY 0952-5041 (2018) DOI / 10.1530/jme-17-0263 Bronze
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Article Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice Leon, Silvia; Velasco, Inmaculada; Vazquez, Maria J.; Barroso, Alexia; Beiroa, Daniel; Heras, Violeta; Ruiz-Pino, Francisco; Manfredi-Lozano, Maria; Romero-Ruiz, Antonio; Sanchez-Garrido, Miguel A.; Dieguez, Carlos; Pinilla, Leonor; Roa, Juan; Nogueiras, R METABOLISM-CLINICAL AND EXPERIMENTAL 0026-0495 (2018) DOI / 10.1016/j.metabol.2018.07.003
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Article Metabolic Landscape of the Mouse Liver by Quantitative P-31 Nuclear Magnetic Resonance Analysis of the Phosphorome Bernardo-Seisdedos, Ganeko; Bilbao, Jon; Fernandez-Ramos, David; Lopitz-Otsoa, Fernando; Gutierrez de Juan, Virginia; Bizkarguenaga, Maider; Mateos, Borja; Fondevila, Marcos F.; Abril-Fornaguera, Jordi; Diercks, Tammo; Lu, Shelly C.; Nogueiras, Ruben; Mato HEPATOLOGY 0270-9139 (2021) DOI / 10.1002/hep.31676 Hybrid
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Article Oral Pharmacological Activation of Hypothalamic Guanylate Cyclase 2C Receptor Stimulates Brown Fat Thermogenesis to Reduce Body Weight Folgueira, Cintia; Leonardo Torres-Leal, Francisco; Beiroa, Daniel; Pena-Leon, Veronica; Da Silva Lima, Natalia; Milbank, Edward; Senra, Ana; Al-Massadi, Omar; Lopez, Miguel; Dieguez, Carlos; Seoane, Luisa M.; Nogueiras, Ruben NEUROENDOCRINOLOGY 0028-3835 (2020) DOI / 10.1159/000505972
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Article Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue Novelle, Marta G.; Vazquez, Maria J.; Peinado, Juan R.; Martinello, Katia D.; Lopez, Miguel; Luckman, Simon M.; Tena-Sempere, Manuel; Malagon, Mara M.; Nogueiras, Ruben; Dieguez, Carlos SCIENTIFIC REPORTS 2045-2322 (2017) DOI / 10.1038/srep46194 Green published, Gold
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Article Activity-Based Anorexia Induces Browning of Adipose Tissue Independent of Hypothalamic AMPK Fraga, Angela; Rial-Pensado, Eva; Nogueiras, Ruben; Ferno, Johan; Dieguez, Carlos; Gutierrez, Emilio; Lopez, Miguel FRONTIERS IN ENDOCRINOLOGY 1664-2392 (2021) DOI / 10.3389/fendo.2021.669980 Gold DOAJ, Green published

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