Biology & Biochemistry

Listando 23 trabajos del autor/autora 38

Lista de trabajos en el área Biology & Biochemistry

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Article Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening Abian, Olga; Ortega-Alarcon, David; Jimenez-Alesanco, Ana; Ceballos-Laita, Laura; Vega, Sonia; Reyburn, Hugh T.; Rizzuti, Bruno; Velazquez-Campoy, Adrian INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 0141-8130 (2020) DOI / 10.1016/j.ijbiomac.2020.07.235 Bronze, Green published

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Article Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M-pro and Its Antiviral Activity in Cells against SARS-CoV-2 Mangiavacchi, Francesca; Botwina, Pawel; Menichetti, Elena; Bagnoli, Luana; Rosati, Ornelio; Marini, Francesca; Fonseca, Sergio F.; Abenante, Laura; Alves, Diego; Dabrowska, Agnieszka; Kula-Pacurar, Anna; Ortega-Alarcon, David; Jimenez-Alesanco, Ana; Cebal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 (2021) DOI / 10.3390/ijms22137048 Gold, Green published

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Article Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma Neira, Jose L.; Bintz, Jennifer; Arruebo, Maria; Rizzuti, Bruno; Bonacci, Thomas; Vega, Sonia; Lanas, Angel; Velazquez-Campoy, Adrian; Iovanna, Juan L.; Abian, Olga SCIENTIFIC REPORTS 2045-2322 (2017) DOI / 10.1038/srep39732 Green published, Gold

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Article Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs Rizzuti, Bruno; Grande, Fedora; Conforti, Filomena; Jimenez-Alesanco, Ana; Ceballos-Laita, Laura; Ortega-Alarcon, David; Vega, Sonia; Reyburn, Hugh T.; Abian, Olga; Velazquez-Campoy, Adrian BIOMEDICINES (2021) DOI / 10.3390/biomedicines9040375 Green published, Gold

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Article DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target Butron, Daniel; Zamora-Carreras, Hector; Devesa, Isabel; Trevino, Miguel A.; Abian, Olga; Velazquez-Campoy, Adrian; Bonache, M. Angeles; Lagartera, Laura; Martin-Martinez, Mercedes; Gonzalez-Rodriguez, Sara; Baamonde, Ana; Fernandez-Carvajal, Asia; Ferrer- BIOORGANIC CHEMISTRY 0045-2068 (2021) DOI / 10.1016/j.bioorg.2021.105231

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Article Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2 Ortega-Alarcon, David; Claveria-Gimeno, Rafael; Vega, Sonia; Jorge-Torres, Olga C.; Esteller, Manel; Abian, Olga; Velazquez-Campoy, Adrian BIOMOLECULES (2020) DOI / 10.3390/biom10111533 Gold, Green published

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Article Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors Felix, Jan; Weinhaupl, Katharina; Chipot, Christophe; Dehez, Francois; Hessel, Audrey; Gauto, Diego F.; Morlot, Cecile; Abian, Olga; Gutsche, Irina; Velazquez-Campoy, Adrian; Schanda, Paul; Fraga, Hugo SCIENCE ADVANCES 2375-2548 (2019) DOI / 10.1126/sciadv.aaw3818 Green published, Green submitted, Gold

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Article The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site Claveria-Gimeno, Rafael; Lanuza, Pilar M.; Morales-Chueca, Ignacio; Jorge-Torres, Olga C.; Vega, Sonia; Abian, Olga; Esteller, Manel; Velazquez-Campoy, Adrian SCIENTIFIC REPORTS 2045-2322 (2017) DOI / 10.1038/srep41635 Green published, Gold, Green submitted

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Article Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2 Ortega-Alarcon, David; Claveria-Gimeno, Rafael; Vega, Sonia; Jorge-Torres, Olga C.; Esteller, Manel; Abian, Olga; Velazquez-Campoy, Adrian BIOMOLECULES (2021) DOI / 10.3390/biom11081216 Gold, Green published

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Article Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction Ortega-Alarcon, David; Claveria-Gimeno, Rafael; Vega, Sonia; Jorge-Torres, Olga C.; Esteller, Manel; Abian, Olga; Velazquez-Campoy, Adrian INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 0141-8130 (2021) DOI / 10.1016/j.ijbiomac.2021.01.206 Green published

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Article Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1 Neira, Jose L.; Correa, Juan; Rizzuti, Bruno; Santofimia-Castano, Patricia; Abian, Olga; Velazquez-Campoy, Adrian; Fernandez-Megia, Eduardo; Iovanna, Juan L. BIOMACROMOLECULES 1525-7797 (2019) DOI / 10.1021/acs.biomac.9b00378

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Review Targeting intrinsically disordered proteins involved in cancer Santofimia-Castano, Patricia; Rizzuti, Bruno; Xia, Yi; Abian, Olga; Peng, Ling; Velazquez-Campoy, Adrian; Neira, Jose L.; Iovanna, Juan CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X (2020) DOI / 10.1007/s00018-019-03347-3 Gold other, Green published

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Article A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin Neira, Jose L.; Rizzuti, Bruno; Jimenez-Alesanco, Ana; Palomino-Schatzlein, Martina; Abian, Olga; Velazquez-Campoy, Adrian; Iovanna, Juan L. BIOMOLECULES (2020) DOI / 10.3390/biom10091313 Green published, Gold

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Article Fluorescence Liquid Biopsy for Cancer Detection Is Improved by Using Cationic Dendronized Hyperbranched Polymer Morcuende-Ventura, Violeta; Hermoso-Duran, Sonia; Abian-Franco, Natalia; Pazo-Cid, Roberto; Ojeda, Jorge L.; Vega, Sonia; Sanchez-Gracia, Oscar; Velazquez-Campoy, Adrian; Sierra, Teresa; Abian, Olga INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 (2021) DOI / 10.3390/ijms22126501 Gold, Green published

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Article l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells Sancineto, Luca; Ostacolo, Carmine; Ortega-Alarcon, David; Jimenez-Alesanco, Ana; Ceballos-Laita, Laura; Vega, Sonia; Abian, Olga; Velazquez-Campoy, Adrian; Moretti, Silvia; Dabrowska, Agnieszka; Botwina, Pawel; Synowiec, Aleksandra; Kula-Pacurar, Anna; Py MOLECULES (2021) DOI / 10.3390/molecules26196062 Green published, Gold