Pharmacology & Toxicology


  Listando 39 trabajos del autor/autora 38
Lista de trabajos en el área Pharmacology & Toxicology
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Article WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "beta-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-beta-Lactamase-Producing High-Risk Clones Moya, Bartolome; Barcelo, Isabel M.; Bhagwat, Sachin; Patel, Mahesh; Bou, German; Papp-Wallace, Krisztina M.; Bonomo, Robert A.; Oliver, Antonio ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2017) DOI / 10.1128/aac.02529-16 Green published, Bronze
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Article Spanish nationwide survey on Pseudomonas aeruginosa antimicrobial resistance mechanisms and epidemiology del Barrio-Tofino, Ester; Zamorano, Laura; Cortes-Lara, Sara; Lopez-Causape, Carla; Sanchez-Diener, Irina; Cabot, Gabriel; Bou, German; Martinez-Martinez, Luis; Oliver, Antonio; Galan, Fatima; Gracia, Irene; Rodriguez, Manuel Antonio; Martin, Lina; Sanchez JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2019) DOI / 10.1093/jac/dkz147
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Article Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extendedspectrum- beta-lactamase-producing Enterobacteriaceae Raquel Palacios-Baena, Zaira; Gutierrez-Gutierrez, Belen; de Cueto, Marina; Viale, Pierluigi; Venditti, Mario; Hernandez-Torres, Alicia; Oliver, Antonio; Martinez-Martinez, Luis; Calbo, Esther; Pintado, Vicente; Gasch, Oriol; Almirante, Benito; Antonio Lep JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkw513 Green published, Bronze
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Article Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System Fernandez-Garcia, Laura; Fernandez-Cuenca, Felipe; Blasco, Lucia; Lopez-Rojas, Rafael; Ambroa, Anton; Lopez, Maria; Pascual, Alvaro; Bou, German; Tomas, Maria ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2018) DOI / 10.1128/aac.00250-18 Green published, Gold other
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Article Activity of Imipenem-Relebactam against a Large Collection of Pseudomonas aeruginosa Clinical Isolates and lsogenic beta-Lactam-Resistant Mutants Fraile-Ribot, Pablo A.; Zamorano, Laura; Orellana, Rocio; del Barrio-Tofino, Ester; Sanchez-Diener, Irina; Cortes-Lara, Sara; Lopez-Causape, Carla; Cabot, Gabriel; Bou, German; Martinez-Martinez, Luis; Oliver, Antonio; Galan, Fatima; Gracia, Irene; Antonio ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2020) DOI / 10.1128/aac.02165-19 Bronze, Green published
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Review CRISPR-Cas, a Revolution in the Treatment and Study of ESKAPE Infections: Pre-Clinical Studies Gonzalez de Aledo, Manuel; Gonzalez-Bardanca, Monica; Blasco, Lucia; Pacios, Olga; Bleriot, Ines; Fernandez-Garcia, Laura; Fernandez-Quejo, Melisa; Lopez, Maria; Bou, German; Tomas, Maria ANTIBIOTICS-BASEL 2079-6382 (2021) DOI / 10.3390/antibiotics10070756 Green published
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Article Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections Arca-Suarez, Jorge; Lasarte-Monterrubio, Cristina; Rodino-Janeiro, Bruno-Kotska; Cabot, Gabriel; Carlos Vazquez-Ucha, Juan; Rodriguez-Iglesias, Manuel; Galan-Sanchez, Fatima; Beceiro, Alejandro; Gonzalez-Bello, Concepcion; Oliver, Antonio; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2021) DOI / 10.1093/jac/dkaa396
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Article Association between Pseudomonas aeruginosa O-antigen serotypes, resistance profiles and high-risk clones: results from a Spanish nationwide survey del Barrio-Tofino, Ester; Sanchez-Diener, Irina; Zamorano, Laura; Cortes-Lara, Sara; Lopez-Causape, Carla; Cabot, Gabriel; Bou, German; Martinez-Martinez, Luis; Oliver, Antonio; Galan, Fatima; Gracia, Irene; Antonio Rodriguez, Manuel; Martin, Lina; Manuel JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2019) DOI / 10.1093/jac/dkz346 Green accepted
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Article Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal depicted by WGS Hernandez-Garcia, Marta; Garcia-Castillo, Maria; Garcia-Fernandez, Sergio; Melo-Cristino, Jose; Pinto, Margarida F.; Goncalves, Elsa; Alves, Valquiria; Vieira, Ana Raquel; Ramalheira, Elmano; Sancho, Luisa; Diogo, Jose; Ferreira, Rui; Silva, Tania; Chaves, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2021) DOI / 10.1093/jac/dkaa430
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Review (p)ppGpp and Its Role in Bacterial Persistence: New Challenges Pacios, Olga; Blasco, Lucia; Bleriot, Ines; Fernandez-Garcia, Laura; Ambroa, Anton; Lopez, Maria; Bou, German; Canton, Rafael; Garcia-Contreras, Rodolfo; Wood, Thomas K.; Tomas, Maria ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2020) DOI / 10.1128/aac.01283-20 Green published
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Article Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa Moya, Bartolome; Bhagwat, Sachin; Cabot, Gabriel; Bou, German; Patel, Mahesh; Oliver, Antonio JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2020) DOI / 10.1093/jac/dkaa036
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Article Potent beta-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates Moya, Bartolome; Barcelo, Isabel M.; Bhagwat, Sachin; Patel, Mahesh; Bou, German; Papp-Wallace, Krisztina M.; Bonomo, Robert A.; Oliver, Antonio ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2017) DOI / 10.1128/aac.01238-17 Bronze, Green published
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Article 6-Halopyridylmethylidene Penicillin-Based Sulfones Efficiently Inactivate the Natural Resistance of Pseudomonas aeruginosa to beta-Lactam Antibiotics Vazquez-Ucha, Juan C.; Rodriguez, Diana; Lasarte-Monterrubio, Cristina; Lence, Emilio; Arca-Suarez, Jorge; Maneiro, Maria; Gato, Eva; Perez, Astrid; Martinez-Guitian, Marta; Juan, Carlos; Oliver, Antonio; Bou, German; Gonzalez-Bello, Concepcion; Beceiro, A JOURNAL OF MEDICINAL CHEMISTRY 0022-2623 (2021) DOI / 10.1021/acs.jmedchem.1c00369
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Article Activity of the beta-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D beta-Lactamases from Acinetobacter baumannii Vazquez-Ucha, Juan Carlos; Maneiro, Maria; Martinez-Guitian, Marta; Buynak, John; Bethel, Christopher R.; Bonomo, Robert A.; Bou, German; Poza, Margarita; Gonzalez-Bello, Concepcion; Beceiro, Alejandro ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2017) DOI / 10.1128/aac.01172-17 Green accepted, Green published, Bronze
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Article Towards the early detection of beta-lactamase-producing Enterobacteriaceae by MALDI-TOF MS analysis Oviano, Marina; Gomara, Marta; Jose Barba, Maria; Jose Revillo, Maria; Pedro Barbeyto, Luis; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkx127 Bronze
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Article Rapid direct detection of carbapenemase-producing Enterobacteriaceae in clinical urine samples by MALDI-TOF MS analysis Oviano, Marina; de la Luna Ramirez, Cecilia; Pedro Barbeyto, Luis; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkw579 Bronze
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Article Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii Carlos Vazquez-Ucha, Juan; Martinez-Guitian, Marta; Maneiro, Maria; Conde-Perez, Kelly; Alvarez-Fraga, Laura; Torrens, Gabriel; Oliver, Antonio; Buynak, John D.; Bonomo, Robert A.; Bou, German; Gonzalez-Bello, Concepcion; Poza, Margarita; Beceiro, Alejandr ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2019) DOI / 10.1128/aac.01092-19 Green published, Bronze
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Review Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases Pacios, Olga; Blasco, Lucia; Bleriot, Ines; Fernandez-Garcia, Laura; Gonzalez Bardanca, Monica; Ambroa, Anton; Lopez, Maria; Bou, German; Tomas, Maria ANTIBIOTICS-BASEL 2079-6382 (2020) DOI / 10.3390/antibiotics9020065 Gold DOAJ, Green published
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Article Enhanced Antibacterial Activity of Repurposed Mitomycin C and Imipenem in Combination with the Lytic Phage vB_KpnM-VAC13 against Clinical Isolates of Klebsiella pneumoniae Pacios, Olga; Fernandez-Garcia, Laura; Bleriot, Ines; Blasco, Lucia; Gonzalez-Bardanca, Monica; Lopez, Maria; Fernandez-Cuenca, Felipe; Oteo, Jesus; Pascual, Alvaro; Martinez-Martinez, Luis; Domingo-Calap, Pilar; Bou, German; Tomas, Maria ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2021) DOI / 10.1128/aac.00900-21
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Article Rapid Detection of Antibiotic Resistance in Gram-Negative Bacteria Through Assessment of Changes in Cellular Morphology Otero, Fatima; Santiso, Rebeca; Tamayo, Maria; Luis Fernandez, Jose; Bou, German; Antonio Lepe, Jose; McConnell, Michael J.; Gosalvez, Jaime; Miguel Cisneros, Jose MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2016.0023
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Article Anti-adhesive activity of a Vaccinium corymbosum polyphenolic extract targeting intestinal colonization by Klebsiella pneumoniae Gato, Eva; Rosalowska, Alicja; Martinez-Guitian, Marta; Lores, Marta; Bou, German; Perez, Astrid BIOMEDICINE & PHARMACOTHERAPY 0753-3322 (2020) DOI / 10.1016/j.biopha.2020.110885 Gold
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Article Reporting antimicrobial susceptibilities and resistance phenotypes in Acinetobacter spp: a nationwide proficiency study Fernandez-Cuenca, Felipe; Tomas, Maria; Caballero-Moyano, Francisco-Javier; Bou, German; Pascual, Alvaro JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2018) DOI / 10.1093/jac/dkx464 Bronze
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Article In Vitro and In Vivo Activities of beta-Lactams in Combination with the Novel beta-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-beta-Lactamase-Producing Klebsiella pneumoniae Moya, Bartolome; Barcelo, Isabel M.; Cabot, Gabriel; Torrens, Gabriel; Palwe, Snehal; Joshi, Prashant; Umarkar, Kushal; Takalkar, Swapna; Periasamy, Hariharan; Bhagwat, Sachin; Patel, Mahesh; Bou, German; Oliver, Antonio ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2019) DOI / 10.1128/aac.00128-19 Green published, Bronze
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Article Molecular and biochemical insights into the in vivo evolution of AmpC-mediated resistance to ceftolozane/tazobactam during treatment of an MDR Pseudomonas aeruginosa infection Arca-Suarez, Jorge; Vazquez-Ucha, Juan Carlos; Fraile-Ribot, Pablo Arturo; Lence, Emilio; Cabot, Gabriel; Martinez-Guitian, Marta; Lasarte-Monterrubio, Cristina; Rodriguez-Iglesias, Manuel; Beceiro, Alejandro; Gonzalez-Bello, Concepcion; Galan-Sanchez, Fat JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2020) DOI / 10.1093/jac/dkaa291
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Article High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial Perez, Astrid; Gato, Eva; Perez-Llarena, Jose; Fernandez-Cuenca, Felipe; Jose Gude, Maria; Oviano, Marina; Eugenia Pachon, Maria; Garnacho, Jose; Gonzalez, Veronica; Pascual, Alvaro; Miguel Cisneros, Jose; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2019) DOI / 10.1093/jac/dkz030 Bronze
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Article MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae Delgado-Valverde, Mercedes; Valiente-Mendez, Adoracion; Torres, Eva; Almirante, Benito; Gomez-Zorrilla, Silvia; Borrell, Nuria; Isabel Aller-Garcia, Ana; Gurgui, Mercedes; Almela, Manel; Sanz, Mercedes; Bou, German; Martinez-Martinez, Luis; Canton, Rafael; JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkw562 Bronze
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Article Activity of ceftolozane/tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates recovered from intensive care unit patients in Spain: The SUPERIOR multicentre study Garcia-Fernandez, Sergio; Garcia-Castillo, Maria; Bou, German; Calvo, Jorge; Cercenado, Emilia; Delgado, Mercedes; Pitart, Cristina; Mulet, Xavier; Tormo, Nuria; Lopez Mendoza, Diego; Diaz-Reganon, Jazmin; Canton, Rafael; Oliver, Antonio; Pascual, Alvaro; INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 0924-8579 (2019) DOI / 10.1016/j.ijantimicag.2019.02.004
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Article Syzygium aromaticum (clove) and Thymus zygis (thyme) essential oils increase susceptibility to colistin in the nosocomial pathogens Acinetobacter baumannii and Klebsiella pneumoniae Vazquez-Ucha, Juan C.; Martinez-Guitian, Marta; Lasarte-Monterrubio, Cristina; Conde-Perez, Kelly; Arca-Suarez, Jorge; Alvarez-Fraga, Laura; Perez, Astrid; Crecente-Campo, Jose; Alonso, Maria J.; Bou, German; Poza, Margarita; Beceiro, Alejandro BIOMEDICINE & PHARMACOTHERAPY 0753-3322 (2020) DOI / 10.1016/j.biopha.2020.110606 Gold other
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Article Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains ofKlebsiella pneumoniaeProducers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK Bleriot, Ines; Blasco, Lucia; Delgado-Valverde, Mercedes; Gual-de-Torrella, Ana; Ambroa, Anton; Fernandez-Garcia, Laura; Lopez, Maria; Oteo-Iglesias, Jesus; Wood, Thomas K.; Pascual, Alvaro; Bou, German; Fernandez-Cuenca, Felipe; Tomas, Maria TOXINS (2020) DOI / 10.3390/toxins12090566 Gold other, Green published
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Article In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the SpongeAgelas dilatata, againstPseudomonas aeruginosa Pech-Puch, Dawrin; Perez-Povedano, Mar; Martinez-Guitian, Marta; Lasarte-Monterrubio, Cristina; Vazquez-Ucha, Juan Carlos; Bou, German; Rodriguez, Jaime; Beceiro, Alejandro; Jimenez, Carlos MARINE DRUGS (2020) DOI / 10.3390/md18060326 Gold DOAJ, Green published
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Article Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone Arca-Suarez, Jorge; Fraile-Ribot, Pablo; Carlos Vazquez-Ucha, Juan; Cabot, Gabriel; Martinez-Guitian, Marta; Lence, Emilio; Gonzalez-Bello, Concepcion; Beceiro, Alejandro; Rodriguez-Iglesias, Manuel; Galan-Sanchez, Fatima; Bou, German; Oliver, Antonio ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2019) DOI / 10.1128/aac.01110-19 Green published, Bronze
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Letter Quantitative and automated MALDI-TOF MS-based detection of the plasmid-mediated quinolone resistance determinant AAC(6 ')-Ib-cr in Enterobacteriaceae Oviano, Marina; Gomara, Marta; Jose Barba, Maria; Sparbier, Katrin; Pascual, Alvaro; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkx218 Bronze
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Article Simple and Fast Detection of Resistance to Antibiotic Inhibitors of Protein Synthesis in Gram-Negative Pathogens Through Evaluation of Mitomycin C-Induced Cell Elongation Otero, Fatima; Gosalvez, Jaime; Bou, German; Luis Fernandez, Jose MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2017.0028
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Article Antisense inhibition of lpxB gene expression in Acinetobacter baumannii by peptide-PNA conjugates and synergy with colistin Martinez-Guitian, Marta; Carlos Vazquez-Ucha, Juan; Alvarez-Fraga, Laura; Conde-Perez, Kelly; Bou, German; Poza, Margarita; Beceiro, Alejandro JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2020) DOI / 10.1093/jac/dkz409
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Article Marine Organisms from the Yucatan Peninsula (Mexico) as a Potential Natural Source of Antibacterial Compounds Pech-Puch, Dawrin; Perez-Povedano, Mar; Gomez, Patricia; Martinez-Guitian, Marta; Lasarte-Monterrubio, Cristina; Carlos Vazquez-Ucha, Juan; Lourdes Novoa-Olmedo, Maria; Guillen-Hernandez, Sergio; Villegas-Hernandez, Harold; Bou, German; Rodriguez, Jaime; B MARINE DRUGS (2020) DOI / 10.3390/md18070369 Gold DOAJ, Green published
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Article Clinical management of cUTI, cIAI, and HABP/VABP attributable to carbapenem-resistant Gram-negative infections in Spain Ferrer, Ricard; Carmen Farinas, Maria; Maseda, Emilio; Salavert, Miguel; Bou, German; Diaz-Reganon, Jazmin; Lopez, Diego; Lozano, Virginia; Gomez-Ulloa, David; Fenoll, Raquel; Lara, Nuria; McCann, Eilish REVISTA ESPANOLA DE QUIMIOTERAPIA (2021) DOI / 10.37201/req/096.2021
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Article Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the beta-Lactamase Inhibitor LN-1-255 against Acinetobacter spp. Lasarte-Monterrubio, Cristina; Vazquez-Ucha, Juan C.; Maneiro, Maria; Arca-Suarez, Jorge; Alonso, Isaac; Guijarro-Sanchez, Paula; Buynak, John D.; Bou, German; Gonzalez-Bello, Concepcion; Beceiro, Alejandro ANTIBIOTICS-BASEL 2079-6382 (2021) DOI / 10.3390/antibiotics10020210 Green published, Gold
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Article Rapid Assessment of Resistance to Antibiotic Inhibitors of Protein Synthesis in the Gram-Positive Pathogens, Enterococcus faecalis and Streptococcus pneumoniae, Based on Evaluation of the Lytic Response Otero, Fatima; Tamayo, Maria; Santiso, Rebeca; Gosalvez, Jaime; Bou, German; Luis Fernandez, Jose MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2016.0091
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Article Increased Antimicrobial Resistance in a Novel CMY-54 AmpC-Type Enzyme with a GluLeu(217-218) Insertion in the -Loop Jose Perez-Llarena, Francisco; Carlos Vazquez-Ucha, Juan; Kerff, Frederic; Zamorano, Laura; Miro, Elisenda; Povoa Cabral, Maria; Fleites, Ana; Lantero, Marta; Martinez-Martinez, Luis; Oliver, Antonio; Galleni, Moreno; Navarro, Ferran; Beceiro, Alejandro; B MICROBIAL DRUG RESISTANCE 1076-6294 (2018) DOI / 10.1089/mdr.2017.0017

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