Pharmacology & Toxicology
Listando 26 trabajos del autor/autora 38
Lista de trabajos en el área Pharmacology & Toxicology
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Article
Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile
Bautista-Aguilera, Oscar M.; Budni, Josiane; Mina, Francielle; Medeiros, Eduarda Behenck; Deuther-Conrad, Winnie; Entrena, Jose M.; Moraleda, Ignacio; Iriepa, Isabel; Lopez-Munoz, Francisco; Marco-Contelles, Jose
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2018)
DOI /
10.1021/acs.jmedchem.8b00848
Mentions
58
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1
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3
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0
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Article
Quinolinyl Nitrone RP19 Induces Neuroprotection after Transient Brain Ischemia
Ayuso, Maria I.; Martinez-Alonso, Emma; Chioua, Mourad; Escobar-Peso, Alejandro; Gonzalo-Gobernado, Rafael; Montaner, Joan; Marco-Contelles, Jose; Alcazar, Alberto
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2017)
DOI /
10.1021/acschemneuro.7b00126
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5
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1
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Review
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy
do Carmo Carreiras, Maria; Ismaili, Lhassane; Marco-Contelles, Jose
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
0960-894X (2020)
DOI /
10.1016/j.bmcl.2019.126880
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1
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0
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1
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Editorial Material
Facts, Results, and Perspectives of the Current Alzheimer's Disease Research
Marco-Contelles, Jose
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2019)
DOI /
10.1021/acschemneuro.9b00034
Bronze
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1
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1
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Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents
Silva, Daniel; Mendes, Eduarda; Summers, Eleanor J.; Neca, Ana; Jacinto, Ana C.; Reis, Telma; Agostinho, Paula; Bolea, Irene; Luisa Jimeno, M.; Luisa Mateus, M.; Oliveira-Campos, Ana M. F.; Unzeta, Mercedes; Marco-Contelles, Jose; Majekova, Magdalena; Rams
DRUG DEVELOPMENT RESEARCH
0272-4391 (2019)
DOI /
10.1002/ddr.21594
Green accepted
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0
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1
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Article
Donepezil plus chromone plus melatonin hybrids as promising agents for Alzheimer's disease therapy
Pachon-Angona, Irene; Refouvelet, Bernard; Andrys, Rudolf; Martin, Helene; Luzet, Vincent; Iriepa, Isabel; Moraleda, Ignacio; Diez-Iriepa, Daniel; Oset-Gasque, Maria-Jesus; Marco-Contelles, Jose; Musilek, Kamil; Ismaili, Lhassane
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
1475-6366 (2019)
DOI /
10.1080/14756366.2018.1545766
Gold DOAJ, Green published
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0
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1
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Article
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines
de los Rios, Cristobal; Marco-Contelles, Jose
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2019)
DOI /
10.1016/j.ejmech.2019.02.005
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Letter
"A beta Tau", Lobby or Religion?
Marco-Contelles, Jose
ACS MEDICINAL CHEMISTRY LETTERS
1948-5875 (2019)
DOI /
10.1021/acsmedchemlett.9b00439
Green published, Bronze
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0
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1
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Article
Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease
Alonso, Jose M.; Escobar-Peso, Alejandro; Palomino-Antolin, Alejandra; Diez-Iriepa, Daniel; Chioua, Mourad; Martinez-Alonso, Emma; Iriepa, Isabel; Egea, Javier; Alcazar, Alberto; Marco-Contelles, Jose
PHARMACEUTICALS
(2021)
DOI /
10.3390/ph14090861
Gold, Green published
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Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors
Deuther-Conrad, Winnie; Diez-Iriepa, Daniel; Iriepa, Isabel; Lopez-Munoz, Francisco; Martinez-Grau, Maria Angeles; Guetschow, Michael; Marco-Contelles, Jose
RSC MEDICINAL CHEMISTRY
(2021)
DOI /
10.1039/d1md00105a
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0
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1
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Review
Tacrine-Natural-Product Hybrids for Alzheimer's Disease Therapy
Jesus Oset-Gasque, Maria; Luis Marco-Contelles, Jose
CURRENT MEDICINAL CHEMISTRY
0929-8673 (2020)
DOI /
10.2174/0929867325666180403151725
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0
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Article
Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy
Dgachi, Youssef; Martin, Helene; Bonet, Alexandre; Chioua, Mourad; Iriepa, Isabel; Moraleda, Ignacio; Chabchoub, Fakher; Marco-Contelles, Jose; Ismaili, Lhassane
FUTURE MEDICINAL CHEMISTRY
1756-8919 (2017)
DOI /
10.4155/fmc-2017-0004
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1
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Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy
Dgachi, Youssef; Martin, Helene; Malek, Rim; Jun, Daniel; Janockova, Jana; Sepsova, Vendula; Soukup, Ondrej; Iriepa, Isabel; Moraleda, Ignacio; Maalej, Emna; Carmo Carreiras, M.; Refouvelet, Bernard; Chabchoub, Fakher; Marco-Contelles, Jose; Ismaili, Lhass
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
1475-6366 (2019)
DOI /
10.1080/14756366.2018.1538136
Green published, Gold
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1
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0
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Article
Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke
Martinez-Alonso, Emma; Escobar-Peso, Alejandro; Ayuso, Maria, I; Gonzalo-Gobernado, Rafael; Chioua, Mourad; Montoya, Juan J.; Montaner, Joan; Fernandez, Israel; Marco-Contelles, Jose; Alcazar, Alberto
ANTIOXIDANTS
(2020)
DOI /
10.3390/antiox9040291
Gold DOAJ, Green published
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0
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1
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Article
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease
Mezeiova, Eva; Janockova, Jana; Andrys, Rudolf; Soukup, Ondrej; Kobrlova, Tereza; Muckova, Lubica; Pejchal, Jaroslav; Simunkova, Miriama; Handl, Jiri; Micankova, Petra; Capek, Jan; Rousar, Tomas; Hrabinova, Martina; Nepovimova, Eugenie; Luis Marco-Contelle
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2021)
DOI /
10.1016/j.ejmech.2020.113112
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0
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Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
Dgachi, Youssef; Sokolov, Olga; Luzet, Vincent; Godyn, Justyna; Panek, Dawid; Bonet, Alexandre; Martin, Helene; Iriepa, Isabel; Moraleda, Ignacio; Garcia-Iriepa, Cristina; Janockova, Jana; Richert, Lysiane; Soukup, Ondrej; Malawska, Barbara; Chabchoub, Fak
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2017)
DOI /
10.1016/j.ejmech.2016.11.050
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3
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Synthesis, antioxidant properties and neuroprotection of alpha-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models
Chamorro, Beatriz; Diez-Iriepa, Daniel; Meras-Saiz, Belen; Chioua, Mourad; Garcia-Vieira, David; Iriepa, Isabel; Hadjipavlou-Litina, Dimitra; Lopez-Munoz, Francisco; Martinez-Murillo, Ricardo; Gonzalez-Nieto, Daniel; Fernandez, Israel; Marco-Contelles, Jos
SCIENTIFIC REPORTS
2045-2322 (2020)
DOI /
10.1038/s41598-020-70690-y
Green published, Gold
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6
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New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective (Z)-N-tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment
Chioua, Mourad; Martinez-Alonso, Emma; Gonzalo-Gobernado, Rafael; Ayuso, Maria I.; Escobar-Peso, Alejandro; Infantes, Lourdes; Hadjipavlou-Litina, Dimitra; Montoya, Juan J.; Montaner, Joan; Alcazar, Alberto; Marco-Contelles, Jose
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2019)
DOI /
10.1021/acs.jmedchem.8b01987
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1
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Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine
De Deurwaerdere, Philippe; Binda, Claudia; Corne, Remi; Leone, Cosima; Valeri, Aurora; Valoti, Massimo; Ramsay, Rona R.; Fall, Yagamare; Marco-Contelles, Jose
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2017)
DOI /
10.1021/acschemneuro.6b00377
Green accepted
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2
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(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3 beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
Ismaili, Lhassane; Monnin, Julie; Etievant, Adeline; Arribas, Raquel L.; Viejo, Lucia; Refouvelet, Bernard; Soukup, Ondrej; Janockova, Jana; Hepnarova, Vendula; Korabecny, Jan; Kucera, Tomas; Jun, Daniel; Andrys, Rudolf; Musilek, Kamil; Baguet, Aurelie; Ga
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2021)
DOI /
10.1021/acschemneuro.0c00803
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1
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Review
Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines
Romero, Alejandro; Marco-Contelles, Jose
CURRENT TOPICS IN MEDICINAL CHEMISTRY
1568-0266 (2017)
DOI /
10.2174/1568026618666180112155639
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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease
Chioua, Mourad; Buzzi, Eleonora; Moraleda, Ignacio; Iriepa, Isabel; Maj, Maciej; Wnorowski, Artur; Giovannini, Catia; Tramarin, Anna; Portali, Federica; Ismaili, Lhassane; Lopez-Alvarado, Pilar; Laura Bolognesi, Maria; Jozwiak, Krzysztof; Carlos Menendez,
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2018)
DOI /
10.1016/j.ejmech.2018.06.044
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1
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New Tacrines as Anti-Alzheimer's Disease Agents. The (Benzo)Chromeno-PyranoTacrines
Jesus Oset-Gasque, Maria; Marco-Contelles, Jose
CURRENT TOPICS IN MEDICINAL CHEMISTRY
1568-0266 (2017)
DOI /
10.2174/1568026618666180112155928
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1
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Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration
Ramos, Eva; Egea, Javier; de los Rios, Cristobal; Marco-Contelles, Jose; Romero, Alejandro
FUTURE MEDICINAL CHEMISTRY
1756-8919 (2017)
DOI /
10.4155/fmc-2017-0014
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Alzheimer's Disease, the "One-Molecule, One-Target" Paradigm, and the Multitarget Directed Ligand Approach
Jesus Oset-Gasque, Maria; Marco-Contelles, Jose
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2018)
DOI /
10.1021/acschemneuro.8b00069
Bronze
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In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
Wieckowska, Anna; Szalaj, Natalia; Goral, Izabella; Bucki, Adam; Latacz, Gniewomir; Kiec-Kononowicz, Katarzyna; Bautista-Aguilera, Oscar M.; Romero, Alejandro; Ramos, Eva; Egea, Javier; Alins, Victor Farre; Gonzalez-Rodriguez, Agueda; Lopez-Munoz, Francisc
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2020)
DOI /
10.1021/acschemneuro.0c00489
Green published, Gold other
