Pharmacology & Toxicology
Listando 37 trabajos del autor/autora 38
Lista de trabajos en el área Pharmacology & Toxicology
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Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods
Ginex, Tiziana; Garaigorta, Urtzi; Ramirez, David; Castro, Victoria; Nozal, Vanesa; Maestro, Ines; Garcia-Carceles, Javier; Campillo, Nuria E.; Martinez, ANA; Gastaminza, Pablo; Gil, Carmen
PHARMACEUTICALS
(2021)
DOI /
10.3390/ph14040332
Green submitted, Gold, Green published
Mentions
21
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0
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1
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0
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Article
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors
Gandini, Annachiara; Bartolini, Manuela; Tedesco, Daniele; Martinez-Gonzalez, Loreto; Roca, Carlos; Campillo, Nuria E.; Zaldivar-Diez, Josefa; Perez, Concepcion; Zuccheri, Giampaolo; Miti, Andrea; Feoli, Alessandra; Castellano, Sabrina; Petralla, Sabrina;
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2018)
DOI /
10.1021/acs.jmedchem.8b00610
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41
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COVID-19: Drug Targets and Potential Treatments
Gil, Carmen; Ginex, Tiziana; Maestro, Ines; Nozal, Vanesa; Barrado-Gil, Lucia; Angel Cuesta-Geijo, Miguel; Urquiza, Jesus; Ramirez, David; Alonso, Covadonga; Campillo, Nuria E.; Martinez, ANA
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.0c00606
Green published, Green submitted, Bronze
Mentions
20
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1
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Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate
Zaldivar-Diez, Josefa; Li, Lingling; Garcia, Ana M.; Zhao, Wen-Ning; Medina-Menendez, Cristina; Haggarty, Stephen J.; Gil, Carmen; Morales, Aixa, V; Martinez, ANA
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2020)
DOI /
10.1021/acs.jmedchem.9b01752
Green submitted
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11
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1
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Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles
Rojas-Prats, Elisa; Tosat-Bitrian, Carlota; Martinez-Gonzalez, Loreto; Nozal, Vanesa; Perez, Daniel I.; Martinez, ANA
PHARMACEUTICS
(2021)
DOI /
10.3390/pharmaceutics13020180
Gold, Green published
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9
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High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses
Alten, Baris; Yesiltepe, Metin; Bayraktar, Erva; Tas, Sadik Taskin; Gocmen, Ayse Yesim; Kursungoz, Canan; Martinez, ANA; Sara, Yildirim
BRITISH JOURNAL OF PHARMACOLOGY
0007-1188 (2018)
DOI /
10.1111/bph.14500
Green published, Green submitted, Bronze
Mentions
8
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1
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A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential
Uliassi, Elisa; Pena-Altamira, Luis Emiliano; Morales, Aixa V.; Massenzio, Francesca; Petralla, Sabrina; Rossi, Michele; Roberti, Marinella; Martinez Gonzalez, Loreto; Martinez, ANA; Monti, Barbara; Bolognesi, Maria Laura
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2019)
DOI /
10.1021/acschemneuro.8b00242
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5
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1
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TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis
Palomo, Valle; Tosat-Bitrian, Carlota; Nozal, Vanesa; Nagaraj, Siranjeevi; Martin-Requero, Angeles; Martinez, ANA
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2019)
DOI /
10.1021/acschemneuro.9b00026
Green submitted
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4
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Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3 beta
Davies, Matthew P.; Benitez, Rocio; Perez, Concepcion; Jakupovic, Sven; Welsby, Philip; Rzepecka, Klaudia; Alder, Jane; Davidson, Colin; Martinez, ANA; Hayes, Joseph M.
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2021)
DOI /
10.1021/acs.jmedchem.0c01568
Mentions
3
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1
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Protein kinase inhibitors for amyotrophic lateral sclerosis therapy
Palomo, Valle; Nozal, Vanesa; Rojas-Prats, Elisa; Gil, Carmen; Martinez, ANA
BRITISH JOURNAL OF PHARMACOLOGY
0007-1188 (2020)
DOI /
10.1111/bph.15221
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2
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1
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Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3 beta Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease
Di Martino, Rita Maria Concetta; Pruccoli, Letizia; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Martinez, ANA; Perez, Concepcion; Martinez-Gonzalez, Loreto; Paglione, Maria; Di Schiavi, Elia; Seghetti, Francesca; Tarozzi, Andrea; Belluti, Federica
ACS CHEMICAL NEUROSCIENCE
1948-7193 (2020)
DOI /
10.1021/acschemneuro.0c00363
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1
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1
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1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation
Venter, Jana; Perez, Concepcion; van Otterlo, Willem A. L.; Martinez, ANA; Blackie, Margaret A. L.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
0960-894X (2019)
DOI /
10.1016/j.bmcl.2019.04.049
Green submitted
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1
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Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral
Rojas-Prats, Elisa; Martinez-Gonzalez, Loreto; Gonzalo-Consuegra, Claudia; Liachko, Nicole F.; Perez, Concepcion; Ramirez, David; Kraemer, Brian C.; Martin-Requero, Angeles; Perez, Daniel, I; Gil, Carmen; de Lago, Eva; Martinez, ANA
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2021)
DOI /
10.1016/j.ejmech.2020.112968
Mentions
10
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1
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Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target
Garcia-Dorival, Isabel; Angel Cuesta-Geijo, Miguel; Barrado-Gil, Lucia; Galindo, Inmaculada; Garaigorta, Urtzi; Urquiza, Jesus; del Puerto, Ana; Campillo, Nuria E.; Martinez, ANA; Gastaminza, Pablo; Gil, Carmen; Alonso, Covadonga
ANTIVIRAL RESEARCH
0166-3542 (2021)
DOI /
10.1016/j.antiviral.2021.105167
Green published, Hybrid
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3
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Drugs in clinical development for the treatment of amyotrophic lateral sclerosis
Martinez, ANA; Palomo Ruiz, Maria del Valle; Perez, Daniel I.; Gil, Carmen
EXPERT OPINION ON INVESTIGATIONAL DRUGS
1354-3784 (2017)
DOI /
10.1080/13543784.2017.1302426
Green submitted
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0
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Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease
de Andrade, Peterson; Mantoani, Susimaire P.; Goncalves Nunes, Paulo Sergio; Magadan, Carlos Roca; Perez, Concepcion; Xavier, Danilo Jordao; Sakamoto Hojo, Elza Tiemi; Campillo, Nuria E.; Martinez, ANA; Carvalho, Ivone
BIOORGANIC & MEDICINAL CHEMISTRY
0968-0896 (2019)
DOI /
10.1016/j.bmc.2018.12.030
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Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
Sebastian-Perez, Victor; Garcia-Rubia, Alfonso; el-Din, Sayed H. Seif; Sabra, Abdel-Nasser A.; El-Lakkany, Naglaa M.; William, Samia; Blundell, Tom L.; Maes, Louis; Martinez, ANA; Campillo, Nuria E.; Botros, Sanaa S.; Gil, Carmen
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
1475-6366 (2020)
DOI /
10.1080/14756366.2020.1712595
Gold DOAJ, Green published
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2
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In silico identification and in vivo characterization of small molecule therapeutic hypothermia mimetics
Coderch, Claire; Diaz de Cerio, Maria; Maria Zapico, Jose; Pelaez, Rafael; Larrayoz, Ignacio M.; Ramos, Ana; Martinez, Alfredo; de Pascual-Teresa, Beatriz
BIOORGANIC & MEDICINAL CHEMISTRY
0968-0896 (2017)
DOI /
10.1016/j.bmc.2017.10.039
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11
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Identification of new allosteric sites and modulators of AChE through computational and experimental tools
Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Malhotra, Sony; Radoux, Chris; Perez, Concepcion; Martinez, ANA; Antonio Paez, Juan; Blundell, Tom L.; Campillo, Nuria E.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
1475-6366 (2018)
DOI /
10.1080/14756366.2018.1476502
Green published, Gold
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5
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Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators
Roca, Carlos; Martinez-Gonzalez, Loreto; Daniel-Mozo, Miguel; Sastre, Javier; Infantes, Lourdes; Mansilla, Alicia; Chaves-Sanjuan, Antonio; Maria Gonzalez-Rubio, Juana; Gil, Carmen; Javier Canada, H. F.; Martinez, ANA; Jose Sanchez-Barrena, Maria; Campillo
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2018)
DOI /
10.1021/acs.jmedchem.8b00088
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4
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A Triazolotriazine-Based Dual GSK-3 beta/CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition
Redenti, Sara; Marcovich, Irene; De Vita, Teresa; Perez, Concepcion; De Zorzi, Rita; Demitri, Nicola; Perez, Daniel I.; Bottegoni, Giovanni; Bisignano, Paola; Bissaro, Maicol; Moro, Stefano; Martinez, ANA; Storici, Paola; Spalluto, Giampiero; Cavalli, Andr
CHEMMEDCHEM
1860-7179 (2019)
DOI /
10.1002/cmdc.201800778
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3
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Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease
Maestro, Ines; de la Ballina, Laura R.; Simonsen, Anne; Boya, Patricia; Martinez, ANA
ACS CHEMICAL NEUROSCIENCE
(2021)
DOI /
10.1021/acschemneuro.1c00529
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3
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Subtly Modulating Glycogen Synthase Kinase 3 beta: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases
Palomo, Valle; Perez, Daniel I.; Roca, Carlos; Anderson, Cara; Rodriguez-Muela, Natalia; Perez, Concepcion; Morales-Garcia, Jose A.; Reyes, Julio A.; Campillo, Nuria E.; Perez-Castillo, Ana M.; Rubin, Lee L.; Timchenko, Lubov; Gil, Carmen; Martinez, ANA
JOURNAL OF MEDICINAL CHEMISTRY
0022-2623 (2017)
DOI /
10.1021/acs.jmedchem.7b00395
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2
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Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases
Maestro, Ines; Boya, Patricia; Martinez, ANA
EXPERT OPINION ON THERAPEUTIC TARGETS
1472-8222 (2020)
DOI /
10.1080/14728222.2020.1730328
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2
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Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses
Lasala, Fatima; Garcia-Rubia, Alfonso; Requena, Carlos; Galindo, Inmaculada; Cuesta-Geijo, Miguel Angel; Garcia-Dorival, Isabel; Bueno, Paula; Labiod, Nuria; Luczkowiak, Joanna; Martinez, ANA; Campillo, Nuria E.; Alonso, Covadonga; Delgado, Rafael; Gil, Ca
ANTIVIRAL RESEARCH
0166-3542 (2021)
DOI /
10.1016/j.antiviral.2021.105011
Green published
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1
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The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis
Perez-Domper, Paloma; Palomo, Valle; Gradari, Simona; Gil, Carmen; de Ceballos, Maria L.; Martinez, ANA; Luis Trejo, Jose
NEUROPHARMACOLOGY
0028-3908 (2017)
DOI /
10.1016/j.neuropharm.2016.12.019
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2
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Hypothermic Shock Applied After Perinatal Asphyxia Prevents Retinal Damage in Rats
Rey-Funes, Manuel; Contartese, Daniela S.; Pelaez, Rafael; Garcia-Sanmartin, Josune; Narro-Iniguez, Judit; Solino, Manuel; Fernandez, Juan Carlos; Sarotto, Anibal; Ciranna, Nicolas S.; Lopez-Costa, Juan Jose; Dorfman, Veronica B.; Larrayoz, Ignacio M.; Loi
FRONTIERS IN PHARMACOLOGY
(2021)
DOI /
10.3389/fphar.2021.651599
Green published, Gold
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2
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Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases
Bobadilla, Miriam; Garcia-Sanmartin, Josune; Martinez, Alfredo
ANTIOXIDANTS
(2021)
DOI /
10.3390/antiox10010046
Gold, Green published
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2
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Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases
Nozal, Vanesa; Martinez, ANA
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2019)
DOI /
10.1016/j.ejmech.2018.10.030
Green submitted
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1
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Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Sebastian-Perez, Victor; Martinez-Gonzalez, Loreto; Perez, Daniel I.; Perez, Concepcion; Canales, Angeles; Javier Canada, F.; Campillo, Nuria E.; Carvalho, Ivone; Martinez, ANA
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2018)
DOI /
10.1016/j.ejmech.2018.01.007
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1
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From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease
Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Castillo, Willian O.; Moreira, Natalia C. S.; Perez, Concepcion; Sakamoto-Hojo, Elza T.; Takahashi, Catarina S.; Jimenez-Barbero, Jesus; Javier
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2017)
DOI /
10.1016/j.ejmech.2017.08.051
Green submitted
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2
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A Grape Juice Supplemented with Natural Grape Extracts Is Well Accepted by Consumers and Reduces Brain Oxidative Stress
Bobadilla, Miriam; Hernandez, Carlos; Ayala, Maria; Alonso, Ixone; Iglesias, Ana; Garcia-Sanmartin, Josune; Mirpuri, Eduardo; Barriobero, Jose Ignacio; Martinez, Alfredo
ANTIOXIDANTS
(2021)
DOI /
10.3390/antiox10050677
Gold DOAJ, Green published
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2
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Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease
Garcia, Ana M.; Salado, Irene G.; Perez, Daniel I.; Brea, Jose; Morales-Garcia, Jose A.; Gonzalez-Garcia, Alejandro; Cadavid, MariaIsabel; Isabel Loza, Maria; Javier Luque, Francisco; Perez-Castillo, Ana; Martinez, ANA; Gil, Carmen
FUTURE MEDICINAL CHEMISTRY
1756-8919 (2017)
DOI /
10.4155/fmc-2017-0005
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1
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Developing novel classes of protein kinase CK1 delta inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems
Grieco, Ilenia; Bissaro, Maicol; Tiz, Davide Benedetto; Perez, Daniel, I; Perez, Conception; Martinez, ANA; Redenti, Sara; Mariotto, Elena; Bortolozzi, Roberta; Viola, Giampietro; Cozza, Giorgio; Spalluto, Giampiero; Moro, Stefano; Federico, Stephanie
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2021)
DOI /
10.1016/j.ejmech.2021.113331
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2
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Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits
Sebastian-Perez, Victor; Roca, Carlos; Awale, Mahendra; Reymond, Jean-Louis; Martinez, ANA; Gil, Carmen; Campillo, Nuria E.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
1549-9596 (2017)
DOI /
10.1021/acs.jcim.7b00401
Green submitted
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1
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Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3
Lourdes Sciu, M.; Sebastian-Perez, Victor; Martinez-Gonzalez, Loreto; Benitez, Rocio; Perez, Daniel I.; Perez, Concepcion; Campillo, Nuria E.; Martinez, ANA; Laura Moyano, E.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
1475-6366 (2019)
DOI /
10.1080/14756366.2018.1530223
Gold, Green published
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1
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Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents
Salado, Irene G.; Zaldivar-Diez, Josefa; Sebastian-Perez, Victor; Li, Lingling; Geiger, Larissa; Gonzalez, Silvia; Campillo, Nuria E.; Gil, Carmen; Morales, Aixa V.; Perez, Daniel I.; Martinez, ANA
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
0223-5234 (2017)
DOI /
10.1016/j.ejmech.2017.06.060
Green accepted
