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Mitochondria interaction networks show altered topological patterns in Parkinson's disease

Zanin, Massimiliano; Santos, Bruno F. R.; Antony, Paul M. A.; Berenguer-Escuder, Clara; Larsen, Simone B.; Hanss, Zoe; Barbuti, Peter A.; Baumuratov, Aidos S.; Grossmann, Dajana; Capelle, Christophe M.; Weber, Joseph; Balling, Rudi; Ollert, Markus; Krueger

NPJ SYSTEMS BIOLOGY AND APPLICATIONS
2020
VL / 6 - BP / - EP /
abstract
Mitochondrial dysfunction is linked to pathogenesis of Parkinson's disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria interaction networks (MINs). Here we show that MINs formed nonclassical scale-free supernetworks in colonic ganglia both from healthy controls and PD patients; however, altered network topological patterns were observed in PD patients. These patterns were highly correlated with PD clinical scores and a machine-learning approach based on the MIN features alone accurately distinguished between patients and controls with an area-under-curve value of 0.989. The MINs of midbrain dopaminergic neurons (mDANs) derived from several genetic PD patients also displayed specific changes. CRISPR/CAS9-based genome correction of alpha-synuclein point mutations reversed the changes in MINs of mDANs. Our organelle-interaction network analysis opens another critical dimension for a deeper characterization of various complex diseases with mitochondrial dysregulation.

AccesS level

Green published, Gold

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